{"id":2308,"date":"2026-02-02T11:39:07","date_gmt":"2026-02-02T04:39:07","guid":{"rendered":"https:\/\/www.nutrispices.com\/?p=2308"},"modified":"2026-02-02T12:51:09","modified_gmt":"2026-02-02T05:51:09","slug":"co-che-va-vi-tri-tac-dung-cua-kem-oxit","status":"publish","type":"post","link":"https:\/\/www.nutrispices.com\/vi\/nutrinews\/nutricles\/co-che-va-vi-tri-tac-dung-cua-kem-oxit\/","title":{"rendered":"C\u01a1 ch\u1ebf v\u00e0 v\u1ecb tr\u00ed t\u00e1c d\u1ee5ng c\u1ee7a K\u1ebdm oxit ?"},"content":{"rendered":"\n
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K\u1ebdm oxit (ZnO) \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong nhi\u1ec1u th\u1eadp k\u1ef7 nh\u01b0 m\u1ed9t trong nh\u1eefng gi\u1ea3i ph\u00e1p ph\u00f2ng ng\u1eeba ti\u00eau ch\u1ea3y sau cai s\u1eefa hi\u1ec7u qu\u1ea3 nh\u1ea5t cho heo con. Hi\u1ec7u qu\u1ea3 c\u1ee7a ho\u1ea1t ch\u1ea5t n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn r\u1ed9ng r\u00e3i trong th\u1ef1c ti\u1ec5n ch\u0103n nu\u00f4i, tuy nhi\u00ean c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3 kh\u00e1 ph\u1ee9c t\u1ea1p v\u00e0 th\u01b0\u1eddng b\u1ecb \u0111\u01a1n gi\u1ea3n h\u00f3a qu\u00e1 m\u1ee9c. K\u1ebdm oxit th\u01b0\u1eddng \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 nh\u01b0 m\u1ed9t t\u00e1c nh\u00e2n kh\u00e1ng khu\u1ea9n \u0111\u01a1n gi\u1ea3n, d\u1ea7u v\u1eady c\u00e1ch hi\u1ec3u n\u00e0y ch\u01b0a ph\u1ea3n \u00e1nh \u0111\u1ea7y \u0111\u1ee7 t\u00ednh \u0111a d\u1ea1ng c\u1ee7a c\u00e1c c\u01a1 ch\u1ebf v\u1ec1 m\u1eb7t sinh-h\u00f3a-l\u00fd c\u1ee7a ho\u1ea1t ch\u1ea5t n\u00e0y. Tr\u00ean th\u1ef1c t\u1ebf, k\u1ebdm oxit t\u00e1c d\u1ee5ng th\u00f4ng qua nhi\u1ec1u con \u0111\u01b0\u1eddng b\u1ed5 tr\u1ee3 l\u1eabn nhau, ph\u1ee5 thu\u1ed9c v\u00e0o sinh l\u00fd \u0111\u01b0\u1eddng ru\u1ed9t, ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 vi sinh, c\u0169ng nh\u01b0 c\u00e1c \u0111\u1eb7c t\u00ednh n\u1ed9i t\u1ea1i c\u1ee7a ch\u00ednh ngu\u1ed3n k\u1ebdm oxit<\/strong><\/p>\n<\/div><\/div>\n\n\n\n

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\u0110\u1ec3 hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a k\u1ebdm oxit, vi\u1ec7c l\u00e0m r\u00f5 ngu\u1ed3n g\u1ed1c c\u1ee7a vi khu\u1ea9n Escherichia coli <\/em>l\u00e0 r\u1ea5t c\u1ea7n thi\u1ebft. C\u00f3 hai ngu\u1ed3n nhi\u1ec5m ch\u00ednh. <\/p>\n<\/div><\/div>\n\n\n\n

Th\u1ee9 nh\u1ea5t l\u00e0 ngu\u1ed3n n\u1ed9i sinh. C\u00e1c ch\u1ee7ng E. coli<\/em> v\u1ed1n hi\u1ec7n di\u1ec7n t\u1ef1 nhi\u00ean trong \u0111\u01b0\u1eddng ru\u1ed9t heo con, bao g\u1ed3m h\u1ed7ng tr\u00e0ng n\u01a1i duy tr\u00ec m\u1eadt \u0111\u1ed9 E. coli <\/em>th\u1ea5p v\u00e0 trong m\u1ee9c ki\u1ec3m so\u00e1t. Tuy nhi\u00ean, sau cai s\u1eefa, nh\u1eefng thay \u0111\u1ed5i \u0111\u1ed9t ng\u1ed9t v\u1ec1 kh\u1ea9u ph\u1ea7n, stress, h\u1ec7 mi\u1ec5n d\u1ecbch c\u00f2n non y\u1ebfu v\u00e0 s\u1ef1 r\u1ed1i lo\u1ea1n nhu \u0111\u1ed9ng ru\u1ed9t \u0111\u00e3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i \u0111\u1ec3 c\u00e1c vi khu\u1ea9n n\u1ed9i t\u1ea1i n\u00e0y t\u0103ng sinh t\u1ea1i ch\u1ed7 v\u00e0 bi\u1ec3u hi\u1ec7n \u0111\u1ed9c l\u1ef1c. Th\u1ee9 hai l\u00e0 ngu\u1ed3n ngo\u1ea1i sinh. Th\u1ee9c \u0103n c\u00f3 th\u1ec3 \u0111\u01b0a vi khu\u1ea9n E.coli<\/em> v\u00e0o \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, v\u00e0 ch\u00fang c\u00f3 th\u1ec3 t\u0103ng sinh trong d\u1ea1 d\u00e0y, \u0111\u1eb7c bi\u1ec7t \u1edf heo con non. Trong giai \u0111o\u1ea1n cai s\u1eefa, d\u1ecbch ti\u1ebft d\u1ea1 d\u00e0y c\u00f2n h\u1ea1n ch\u1ebf v\u00e0 th\u1eadm ch\u00ed c\u00f2n h\u1ea1n ch\u1ebf h\u01a1n n\u1eefa khi trong th\u00e0nh ph\u1ea7n th\u1ee9c \u0103n c\u00f3 ch\u1ee9a c\u00e1c ch\u1ea5t \u0111\u1ec7m axit nh\u01b0 calcium carbonate.<\/p>\n\n\n\n

Khi pH d\u1ecbch v\u1ecb t\u0103ng, d\u1ea1 d\u00e0y s\u1ebd m\u1ea5t \u0111i m\u1ed9t ph\u1ea7n ch\u1ee9c n\u0103ng c\u1ee7a h\u00e0ng r\u00e0o kh\u00e1ng khu\u1ea9n, t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho vi khu\u1ea9n s\u1ed1ng s\u00f3t \u0111i v\u00e0o ru\u1ed9t non, t\u1eeb \u0111\u00f3 l\u00e0m t\u0103ng \u00e1p l\u1ef1c nhi\u1ec5m khu\u1ea9n
K\u1ebdm oxit t\u00e1c d\u1ee5ng \u1edf hia v\u1ecb tr\u00ed b\u1ed5 tr\u1ee3 l\u1eabn nhau. V\u1ecb tr\u00ed th\u1ee9 nh\u1ea5t \u1edf giai \u0111o\u1ea1n ti\u00eau h\u00f3a d\u1ea1 d\u00e0y. K\u1ebdm oxit h\u1ea1n ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a vi khu\u1ea9n b\u1eb1ng c\u00e1ch gi\u1ea3m kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t c\u1ee7a E. coli<\/em> trong m\u00f4i tr\u01b0\u1eddng acid. Khi s\u1ed1 l\u01b0\u1ee3ng vi khu\u1ea9n c\u00f2n s\u1ed1ng r\u1eddi kh\u1ecfi d\u1ea1 d\u00e0y gi\u1ea3m xu\u1ed1ng, k\u1ebdm oxit gi\u00fap h\u1ea1n ch\u1ebf t\u00ecnh tr\u1ea1ng sinh s\u1ea3n li\u00ean t\u1ee5c c\u1ee7a vi khu\u1ea9n trong ru\u1ed9t non. T\u00e1c d\u1ee5ng n\u00e0y \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng v\u1edbi heo con c\u00f3 axit d\u1ea1 d\u00e0y th\u1ea5p. V\u1ecb tr\u00ed t\u00e1c d\u1ee5ng th\u1ee9 hai di\u1ec5n ra t\u1ea1i bi\u1ec3u m\u00f4 ru\u1ed9t. K\u1ebdm oxit h\u1ed7 tr\u1ee3 t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a \u0111\u01b0\u1eddng ru\u1ed9t th\u00f4ng qua nhi\u1ec1u c\u01a1 ch\u1ebf ph\u1ed1i h\u1ee3p. K\u1ebdm tr\u1ef1c ti\u1ebfp t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n c\u1ee7a protein m\u1ed1i n\u1ed1i li\u00ean k\u1ebft ch\u1eb7t nh\u01b0 occludin, claudins v\u00e0 ZO-1, c\u1ea3i thi\u1ec7n c\u1ea5u tr\u00fac li\u00ean k\u1ebft gi\u1eefa c\u00e1c t\u1ebf b\u00e0o v\u00e0 gi\u1ea3m t\u00ednh th\u1ea5m gian b\u00e0o. Song song \u0111\u00f3, k\u1ebdm th\u00fac \u0111\u1ea9y s\u1ef1 t\u0103ng sinh c\u1ee7a t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t v\u00e0 ph\u1ee5c h\u1ed3i nhung mao sau stress cai s\u1eefa, g\u00f3p ph\u1ea7n kh\u00f4i ph\u1ee5c kh\u1ea3 n\u0103ng h\u1ea5p thu. Vi khu\u1ea9n E. coli<\/em> sinh \u0111\u1ed9c t\u1ed1 ru\u1ed9t l\u00e0m k\u00edch ho\u1ea1t c\u00e1c con \u0111\u01b0\u1eddng ph\u1ee5 thu\u1ed9c cAMP v\u00e0 cGMP trong t\u1ebf b\u00e0o ru\u1ed9t, l\u00e0m cho chloride (Cl) ti\u1ebft ra qu\u00e1 m\u1ee9c v\u00e0 theo \u0111\u00f3 n\u01b0\u1edbc c\u0169ng b\u1ecb m\u1ea5t th\u1ee5 \u0111\u1ed9ng v\u00e0o l\u00f2ng ru\u1ed9t. K\u1ebdm can thi\u1ec7p v\u00e0o c\u00e1c t\u00edn hi\u1ec7u n\u00e0y, gi\u00fap gi\u1ea3m b\u00e0i ti\u1ebft chloride v\u00e0 h\u1ea1n ch\u1ebf th\u1ea5t tho\u00e1t n\u01b0\u1edbc, ngay c\u1ea3 khi \u0111\u1ed9c t\u1ed1 vi khu\u1ea9n v\u1eabn c\u00f2n t\u1ed3n t\u1ea1i. Nh\u1edd \u0111\u00f3, k\u1ebdm oxit kh\u00f4ng ch\u1ec9 t\u0103ng c\u01b0\u1eddng h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 c\u1ee7a ru\u1ed9t m\u00e0 c\u00f2n l\u00e0m suy gi\u1ea3m \u0111\u00e1p \u1ee9ng ti\u1ebft d\u1ecbch, gi\u00fap bi\u1ec3u m\u00f4 ru\u1ed9t h\u1ea1n ch\u1ebf ph\u00e1t sinh s\u1ef1 ti\u00eau ch\u1ea3y, ngay c\u1ea3 khi vi khu\u1ea9n v\u1eabn t\u1ed3n t\u1ea1i trong l\u00f2ng ru\u1ed9t.<\/p>\n\n\n

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Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n c\u1ee7a k\u1ebdm oxit c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn s\u1ef1 gi\u1ea3i ph\u00f3ng c\u00e1c ion k\u1ebdm (Zn\u00b2\u207a), nh\u1eefng ion n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o vi khu\u1ea9n v\u00e0 l\u00e0m r\u1ed1i lo\u1ea1n c\u00e1c h\u1ec7 enzym v\u00e0 s\u1ef1 trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a vi khu\u1ea9n. Tuy nhi\u00ean, hi\u1ec7u qu\u1ea3 n\u00e0y ch\u1ec9 c\u00f3 \u0111\u01b0\u1ee3c khi n\u1ed3ng \u0111\u1ed9 ion Zn\u00b2\u207a \u0111\u1ee7 cao \u1edf v\u1ecb tr\u00ed t\u00e1c d\u1ee5ng. Ch\u1ec9 ri\u00eang ion Zn2+<\/sup> kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 t\u1ea1o ra t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n \u0111\u1eb7c tr\u01b0ng c\u1ee7a k\u1ebdm oxit, \u0111i\u1ec1u n\u00e0y l\u00fd gi\u1ea3i v\u00ec sao k\u1ebdm sulfat kh\u00f4ng \u0111\u1ea1t hi\u1ec7u qu\u1ea3 t\u01b0\u01a1ng t\u1ef1, d\u00f9 cung c\u1ea5p c\u00f9ng h\u00e0m l\u01b0\u1ee3ng k\u1ebdm. S\u1ef1 kh\u00e1c bi\u1ec7t c\u1ed1t l\u00f5i n\u1eb1m \u1edf c\u00e1ch k\u1ebdm oxit gi\u1ea3i ph\u00f3ng ion k\u1ebdm. Kh\u00f4ng gi\u1ed1ng c\u00e1c d\u1ea1ng k\u1ebdm tan nhanh, k\u1ebdm oxit h\u00f2a tan t\u1eeb t\u1eeb, nh\u1edd \u0111\u00f3 t\u1ea1o ra v\u00f9ng n\u1ed3ng \u0111\u1ed9 (gradient) Zn\u00b2\u207a cao ngay xung quanh tinh th\u1ec3 k\u1ebdm oxit. T\u1ea1i khu v\u1ef1c c\u1eadn b\u1ec1 m\u1eb7t h\u1ea1t, n\u1ed3ng \u0111\u1ed9 Zn\u00b2\u207a c\u00f3 th\u1ec3 \u0111\u1ea1t m\u1ee9c \u0111\u1ee7 \u0111\u1ec3 \u1ee9c ch\u1ebf vi khu\u1ea9n, trong khi \u0111\u00f3 n\u1ed3ng \u0111\u1ed9 Zn2+ <\/sup>gi\u1ea3m nhanh ch\u00f3ng theo kho\u1ea3ng c\u00e1ch. Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y th\u1ec3 hi\u1ec7n r\u00f5 nh\u1ea5t \u1edf d\u1ea1 d\u00e0y, n\u01a1i m\u00f4i tr\u01b0\u1eddng axit l\u00e0m k\u1ebdm oxit h\u00f2a tan m\u1ed9t ph\u1ea7n, trong khi \u1edf ru\u1ed9t s\u1ef1 h\u00f2a tan gi\u1ea3m \u0111i do pH x\u1ea5p x\u1ec9 6,5.<\/p>\n\n\n

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B\u00ean c\u1ea1nh s\u1ef1 gi\u1ea3i ph\u00f3ng Zn\u00b2\u207a, k\u1ebdm oxit c\u00f2n th\u1ec3 hi\u1ec7n t\u00ednh kh\u00e1ng khu\u1ea9n ngay tr\u00ean b\u1ec1 m\u1eb7t h\u1ea1t. Khi ti\u1ebfp x\u00fac v\u1edbi n\u01b0\u1edbc v\u00e0 oxy, b\u1ec1 m\u1eb7t n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o ra c\u00e1c lo\u1ea1i oxy ph\u1ea3n \u1ee9ng (ROS), ch\u1eb3ng h\u1ea1n nh\u01b0 g\u1ed1c superoxide (O\u2082\u2022\u207b). Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y x\u1ea3y ra nhi\u1ec1u h\u01a1n trong m\u00f4i tr\u01b0\u1eddng acid, \u0111i\u1ec1u n\u00e0y l\u00fd gi\u1ea3i v\u00ec sao k\u1ebdm oxit ph\u00e1t huy t\u00e1c d\u1ee5ng m\u1ea1nh nh\u1ea5t \u1edf d\u1ea1 d\u00e0y v\u00e0 k\u00e9m hi\u1ec7u qu\u1ea3 h\u01a1n \u1edf ru\u1ed9t. C\u00e1c ROS n\u00e0y ch\u1ec9 t\u1ed3n t\u1ea1i trong th\u1eddi gian r\u1ea5t ng\u1eafn v\u00e0 ch\u1ec9 t\u00e1c \u0111\u1ed9ng \u1edf ph\u1ea1m vi r\u1ea5t g\u1ea7n b\u1ec1 m\u1eb7t h\u1ea1t k\u1ebdm oxit. V\u00ec v\u1eady, t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n c\u1ee7a ch\u00fang ch\u1ec9 x\u1ea3y ra khi vi khu\u1ea9n ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi h\u1ea1t, ch\u1ee9 kh\u00f4ng lan r\u1ed9ng trong m\u00f4i tr\u01b0\u1eddng xung quanh. C\u00e1c ROS t\u00e1c \u0111\u1ed9ng l\u00ean m\u00e0ng t\u1ebf b\u00e0o vi khu\u1ea9n b\u1eb1ng c\u00e1ch l\u00e0m thay \u0111\u1ed5i t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o vi khu\u1ea9n, l\u00e0m t\u0103ng t\u00ednh th\u1ea5m m\u00e0ng v\u00e0 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho ion Zn\u00b2\u207a khu\u1ebfch t\u00e1n v\u00e0o n\u1ed9i b\u00e0o. V\u00ec v\u1eady, hi\u1ec7u qu\u1ea3 kh\u00e1ng khu\u1ea9n c\u1ee7a k\u1ebdm oxit xu\u1ea5t ph\u00e1t t\u1eeb s\u1ef1 hi\u1ec7p \u0111\u1ed3ng gi\u1eefa ROS v\u00e0 Zn\u00b2\u207a \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1ea1i b\u1ec1 m\u1eb7t h\u1ea1t, m\u1ed9t c\u01a1 ch\u1ebf m\u00e0 c\u00e1c lo\u1ea1i k\u1ebdm h\u00f2a tan kh\u00f4ng th\u1ec3 \u0111\u01a1n thu\u1ea7n \u0111\u01b0\u1ee3c t\u00e1i hi\u1ec7n.<\/p>\n\n\n\n

Trong ru\u1ed9t, c\u00e1c h\u1ea1t k\u1ebdm oxit kh\u00f4ng khu\u1ebfch t\u00e1n \u0111\u1ed3ng \u0111\u1ec1u trong l\u00f2ng ru\u1ed9t m\u00e0 \u0111\u01b0\u1ee3c c\u1ed1 \u0111\u1ecbnh trong l\u1edbp ch\u1ea5t nh\u1ea7y ph\u1ee7 l\u00ean bi\u1ec3u m\u00f4 ru\u1ed9t. S\u1ef1 khu tr\u00fa n\u00e0y cho ph\u00e9p k\u1ebdm oxit duy tr\u00ec n\u1ed3ng \u0111\u1ed9 k\u1ebdm c\u1ee5c b\u1ed9 trong ch\u1ea5t nh\u1ea7y\u2013bi\u1ec3u m\u00f4, t\u1eeb \u0111\u00f3 quy\u1ebft \u0111\u1ecbnh hi\u1ec7u qu\u1ea3 t\u00e1c \u0111\u1ed9ng sinh h\u1ecdc.<\/p>\n\n\n\n

M\u1ee9c \u0111\u1ed9 ph\u00e2n b\u1ed1 k\u1ebdm c\u1ee5c b\u1ed9 n\u00e0y quy\u1ebft \u0111\u1ecbnh tr\u1ef1c ti\u1ebfp \u0111\u00e1p \u1ee9ng c\u1ee7a ru\u1ed9t. N\u1ed3ng \u0111\u1ed9 k\u1ebdm cao h\u01a1n v\u00e0 \u0111\u01b0\u1ee3c duy tr\u00ec \u1ed5n \u0111\u1ecbnh h\u01a1n trong l\u1edbp ch\u1ea5t nh\u1ea7y gi\u00fap t\u0103ng c\u01b0\u1eddng ch\u1ee9c n\u0103ng h\u00e0ng r\u00e0o bi\u1ec3u m\u00f4, nh\u1edd \u1ed5n \u0111\u1ecbnh c\u00e1c li\u00ean k\u1ebft ch\u1eb7t gi\u1eefa c\u00e1c t\u1ebf b\u00e0o v\u00e0 \u0111i\u1ec1u h\u00f2a c\u00e1c con \u0111\u01b0\u1eddng ph\u1ee5 thu\u1ed9c cAMP v\u00e0 cGMP. Nh\u1edd \u0111\u00f3 s\u1ef1 b\u00e0i ti\u1ebft ion chloride gi\u1ea3m xu\u1ed1ng, n\u01b0\u1edbc c\u0169ng v\u00ec th\u1ebf m\u00e0 \u0111\u01b0\u1ee3c gi\u1ea3m ti\u1ebft v\u00e0o l\u00f2ng ru\u1ed9t.<\/p>\n\n\n\n

V\u1ec1 kh\u1ea3 n\u0103ng \u0111\u1ea1t \u0111\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 ion Zn\u00b2\u207a v\u00e0 ROS \u0111\u1ee7 cao trong d\u1ea1 d\u00e0y \u0111\u1ec3 t\u1ea1o ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n l\u1eabn trong ru\u1ed9t \u0111\u1ec3 b\u1ea3o v\u1ec7 bi\u1ec3u m\u00f4, kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 c\u00e1c ngu\u1ed3n k\u1ebdm oxit \u0111\u1ec1u ho\u1ea1t \u0111\u1ed9ng gi\u1ed1ng nhau. C\u00f3 th\u1ec3 ph\u00e2n bi\u1ec7t ba lo\u1ea1i ch\u00ednh. <\/p>\n\n\n\n

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    \n
  1. Lo\u1ea1i 1<\/u><\/strong> = K\u1ebdm oxit tr\u1eafng c\u00f3 k\u00edch th\u01b0\u1edbc h\u1ea1t nh\u1ecf v\u00e0 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t l\u1edbn, th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 k\u1ebdm nano v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn \u1edf ch\u00e2u \u00c1, h\u00f2a tan r\u1ea5t nhanh trong m\u00f4i tr\u01b0\u1eddng axit c\u1ee7a d\u1ea1 d\u00e0y. S\u1ef1 h\u00f2a tan r\u1ea5t nhanh n\u00e0y gi\u1ea3i ph\u00f3ng m\u1ed9t l\u01b0\u1ee3ng l\u1edbn ion Zn\u00b2\u207a trong th\u1eddi gian ng\u1eafn, t\u1ea1o ra \u0111\u1ec9nh k\u1ebdm kh\u00f4ng d\u00e0i.<\/li>\n<\/ol>\n<\/div><\/div>\n\n\n\n

    V\u00ec c\u00e1c ion n\u00e0y \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng m\u00e0 kh\u00f4ng c\u00f3 h\u1ea1t k\u1ebdm oxit r\u1eafn n\u00e0o \u0111\u00f3ng vai tr\u00f2 neo gi\u1eef, ch\u00fang nhanh ch\u00f3ng b\u1ecb pha lo\u00e3ng kh\u1eafp d\u1ecbch v\u1ecb d\u1ea1 d\u00e0y v\u00e0 m\u1ea5t \u0111i n\u1ed3ng \u0111\u1ed9 c\u1ee5c b\u1ed9. \u0110\u1ed3ng th\u1eddi, c\u00e1c ion Zn\u00b2\u207a t\u1ef1 do nhanh ch\u00f3ng b\u1ecb phytate c\u00f3 trong th\u1ee9c \u0103n li\u00ean k\u1ebft. V\u00ec h\u1ea7u h\u1ebft k\u1ebdm oxit \u0111\u00e3 \u0111\u01b0\u1ee3c h\u00f2a tan trong d\u1ea1 d\u00e0y, n\u00ean r\u1ea5t \u00edt ho\u1eb7c kh\u00f4ng c\u00f2n tinh th\u1ec3 k\u1ebdm oxit r\u1eafn n\u00e0o c\u00f2n l\u1ea1i \u0111\u1ec3 \u0111\u1ebfn ru\u1ed9t. Tr\u00ean th\u1ef1c t\u1ebf, ngu\u1ed3n k\u1ebdm oxit n\u00e0y t\u00e1c d\u1ee5ng r\u1ea5t gi\u1ed1ng v\u1edbi mu\u1ed1i k\u1ebdm h\u00f2a tan nh\u01b0 k\u1ebdm sulfat, cung c\u1ea5p ion k\u1ebdm m\u00e0 kh\u00f4ng duy tr\u00ec s\u1ef1\u00a0l\u01b0u tr\u00fa. Do \u0111\u00f3, n\u00f3 kh\u00f4ng th\u1ec3 th\u00e2m nh\u1eadp ho\u1eb7c t\u1ed3n t\u1ea1i hi\u1ec7u qu\u1ea3 trong l\u1edbp ni\u00eam m\u1ea1c ru\u1ed9t, h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng t\u1ea1o ra n\u1ed3ng \u0111\u1ed9 k\u1ebdm cao c\u1ee5c b\u1ed9 \u1edf bi\u1ec3u m\u00f4 v\u00e0 b\u1ea3o v\u1ec7 h\u00e0ng r\u00e0o ru\u1ed9t.<\/p>\n\n\n\n

      <\/ol>\n\n\n\n
      \"\"<\/figure>
      \n

      2. Lo\u1ea1i 2<\/u>\u00a0: K\u1ebdm oxit c\u00f3 k\u00edch th\u01b0\u1edbc h\u1ea1t l\u1edbn v\u00e0 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t th\u1ea5p<\/strong>, m\u00e0u \u0111en, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn \u1edf ch\u00e2u M\u1ef9, h\u00f2a tan ch\u1eadm v\u00e0 cho ph\u00e9p h\u00ecnh th\u00e0nh k\u1ebdm b\u1ec1n v\u1eefng nh\u01b0ng n\u1ed3ng \u0111\u1ed9 ch\u00eanh l\u1ec7ch th\u1ea5p. Tuy nhi\u00ean, \u0111\u1ec3 b\u00f9 \u0111\u1eafp cho n\u1ed3ng \u0111\u1ed9 ch\u00eanh l\u1ec7ch th\u1ea5p n\u00e0y, ng\u01b0\u1eddi ta th\u01b0\u1eddng s\u1eed d\u1ee5ng h\u00e0m l\u01b0\u1ee3ng k\u1ebdm cao l\u00ean \u0111\u1ebfn 3.000 ppm.<\/p>\n<\/div><\/div>\n\n\n\n

      \u1ede li\u1ec1u l\u01b0\u1ee3ng nh\u01b0 v\u1eady, k\u1ebdm oxit g\u00f3p ph\u1ea7n l\u00e0m t\u0103ng pH trong d\u1ea1 d\u00e0y do kh\u1ea3 n\u0103ng \u0111\u1ec7m c\u1ee7a n\u00f3. \u1ede heo con, s\u1ef1 ti\u1ebft axit d\u1ea1 d\u00e0y h\u1ea1n ch\u1ebf, s\u1ef1 t\u0103ng pH n\u00e0y c\u00f3 th\u1ec3 l\u00e0m suy y\u1ebfu h\u00e0ng r\u00e0o kh\u00e1ng khu\u1ea9n c\u1ee7a d\u1ea1 d\u00e0y v\u00e0 ph\u1ea7n n\u00e0o l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a k\u1ebdm oxit.<\/p>\n\n\n\n

      \"\"<\/figure>
      \n

      3. Lo\u1ea1i 3<\/u><\/strong> = K\u1ebdm oxit c\u1ea5u tr\u00fac x\u1ed1p, k\u1ebft h\u1ee3p k\u00edch th\u01b0\u1edbc h\u1ea1t l\u1edbn v\u1edbi di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t r\u1ed9ng<\/strong>, \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 t\u1ed1i \u0111a h\u00f3a kh\u1ea3 n\u0103ng t\u1ed3n t\u1ea1i v\u00e0 ph\u1ea3n \u1ee9ng d\u1ecdc theo \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<\/div><\/div>\n\n\n\n

      C\u1ea5u tr\u00fac v\u1eadt l\u00fd n\u00e0y t\u1ed1i \u01b0u cho vi\u1ec7c t\u1ea1o ra n\u1ed3ng \u0111\u1ed9 Zn\u00b2\u207a c\u1ee5c b\u1ed9 cao xung quanh c\u00e1c tinh th\u1ec3 k\u1ebdm oxit, t\u1ea1o ra m\u1ed9t m\u00f4i tr\u01b0\u1eddng vi m\u00f4 r\u1ea5t b\u1ea5t l\u1ee3i cho s\u1ef1 s\u1ed1ng s\u00f3t c\u1ee7a vi khu\u1ea9n. S\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa l\u00f5i kho\u00e1ng r\u1eafn v\u00e0 b\u1ec1 m\u1eb7t t\u00e1c d\u1ee5ng t\u0103ng cho ph\u00e9p gi\u1ea3i ph\u00f3ng k\u1ebdm li\u00ean t\u1ee5c tr\u1ef1c ti\u1ebfp t\u1ea1i v\u1ecb tr\u00ed h\u1ea1t, thay v\u00ec pha lo\u00e3ng \u0111\u1ed3ng \u0111\u1ec1u trong d\u1ecbch ti\u00eau h\u00f3a.
      Trong d\u1ea1 d\u00e0y, c\u1ea5u tr\u00fac n\u00e0y h\u1ed7 tr\u1ee3 ho\u1ea1t \u0111\u1ed9ng kh\u00e1ng khu\u1ea9n c\u1ee5c b\u1ed9 m\u1ea1nh m\u1ebd th\u00f4ng qua n\u1ed3ng \u0111\u1ed9 k\u1ebdm \u1ed5n \u0111\u1ecbnh m\u00e0 kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o th\u1eddi \u0111i\u1ec3m c\u00e1c ion k\u1ebdm Zn\u00b2\u207a \u0111\u1ea1t \u0111\u1ec9nh ng\u1eafn. Trong ru\u1ed9t, n\u01a1i pH cao h\u01a1n v\u00e0 \u0111\u1ed9 h\u00f2a tan c\u1ee7a k\u1ebdm oxit gi\u1ea3m, c\u00e1c h\u1ea1t k\u1ebdm oxit t\u1ed3n t\u1ea1i trong l\u1edbp ni\u00eam m\u1ea1c v\u00e0 duy tr\u00ec n\u1ed3ng \u0111\u1ed9 Zn\u00b2\u207a c\u1ee5c b\u1ed9 t\u1ea1i bi\u1ec3u m\u00f4. N\u1ed3ng \u0111\u1ed9 n\u00e0y \u0111\u1ee7 \u0111\u1ec3 k\u00edch ho\u1ea1t h\u00e0ng r\u00e0o bi\u1ec3u m\u00f4 v\u00e0 c\u00e1c con \u0111\u01b0\u1eddng ki\u1ec3m so\u00e1t ti\u1ebft d\u1ecbch, gi\u1ea3i th\u00edch hi\u1ec7u qu\u1ea3 v\u01b0\u1ee3t tr\u1ed9i c\u1ee7a k\u1ebdm oxit c\u00f3 \u0111\u1ed9 x\u1ed1p cao trong vi\u1ec7c gi\u1ea3m ti\u00eau ch\u1ea3y sau cai s\u1eefa.<\/p>\n\n\n

      \n
      \"\"<\/figure><\/div>\n\n\n

      K\u1ebdm oxit vi b\u1ecdc<\/u><\/strong> kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t c\u1ea5u tr\u00fac k\u1ebdm oxit \u0111\u1eb7c bi\u1ec7t m\u00e0 l\u00e0 m\u1ed9t s\u1ef1 bi\u1ebfn \u0111\u1ed5i c\u00f4ng ngh\u1ec7 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho m\u1ed9t trong ba lo\u1ea1i k\u1ebdm oxit \u0111\u00e3 m\u00f4 t\u1ea3 \u1edf tr\u00ean. L\u1edbp ph\u1ee7 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 ng\u0103n ng\u1eeba ho\u1eb7c h\u1ea1n ch\u1ebf m\u1ea1nh m\u1ebd s\u1ef1 h\u00f2a tan c\u1ee7a k\u1ebdm oxit trong d\u1ea1 d\u00e0y. K\u1ebft qu\u1ea3 l\u00e0, c\u00e1c ion Zn\u00b2\u207a v\u00e0 ROS ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n c\u00f4ng d\u1ee5ng \u1edf ru\u1ed9t, n\u01a1i k\u1ebdm oxit \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng v\u1edbi t\u1ed1c \u0111\u1ed9 ch\u1eadm h\u01a1n do pH cao h\u01a1n. Do \u0111\u00f3, hi\u1ec7u qu\u1ea3 c\u1ee7a k\u1ebdm oxit vi b\u1ecdc kh\u00f4ng ch\u1ec9 ph\u1ee5 thu\u1ed9c v\u00e0o c\u00f4ng ngh\u1ec7 vi b\u1ecdc m\u00e0 c\u00f2n ph\u1ee5 thu\u1ed9c v\u00e0o c\u00e1c \u0111\u1eb7c t\u00ednh l\u00fd h\u00f3a n\u1ed9i t\u1ea1i c\u1ee7a k\u1ebdm oxit \u0111\u01b0\u1ee3c d\u00f9ng, bao g\u1ed3m k\u00edch th\u01b0\u1edbc h\u1ea1t v\u00e0 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t, n\u00ean \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t bi\u1ec7n ph\u00e1p can thi\u1ec7p t\u00e1c \u0111\u1ed9ng ch\u1ee7 y\u1ebfu \u1edf c\u1ea5p \u0111\u1ed9 ru\u1ed9t m\u00e0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ng\u0103n ch\u1eb7n vi khu\u1ea9n trong d\u1ea1 d\u00e0y.<\/p>\n\n\n\n

      K\u1ebft lu\u1eadn, hi\u1ec7u qu\u1ea3 c\u1ee7a oxit k\u1ebdm (ZnO) kh\u00f4ng th\u1ec3 ch\u1ec9 d\u1ef1a v\u00e0o h\u00e0m l\u01b0\u1ee3ng k\u1ebdm. K\u00edch th\u01b0\u1edbc h\u1ea1t, di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t, \u0111\u1ed9ng h\u1ecdc h\u00f2a tan v\u00e0 c\u00f4ng ngh\u1ec7 ph\u1ee7 vi b\u1ecdc l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 c\u01a1 b\u1ea3n quy\u1ebft \u0111\u1ecbnh ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a n\u00f3. Do \u0111\u00f3, c\u00e1c chuy\u00ean gia dinh d\u01b0\u1ee1ng n\u00ean tr\u00e1nh ch\u1ec9 d\u1ef1a v\u00e0o c\u00e1c c\u00f4ng b\u1ed1 c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t. Ch\u1ec9 c\u00f3 c\u00e1c ph\u00e2n t\u00edch l\u00fd h\u00f3a nghi\u00eam ng\u1eb7t, bao g\u1ed3m ph\u00e2n b\u1ed1 k\u00edch th\u01b0\u1edbc h\u1ea1t v\u00e0 \u0111o di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t, m\u1edbi c\u00f3 th\u1ec3 gi\u00fap \u0111\u00e1nh gi\u00e1 kh\u00e1ch quan c\u00e1c ngu\u1ed3n k\u1ebdm oxit. Ngay c\u1ea3 \u0111\u1ed1i v\u1edbi c\u00e1c s\u1ea3n ph\u1ea9m vi b\u1ecdc, c\u00e1c th\u00f4ng s\u1ed1 n\u00e0y v\u1eabn r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n hi\u1ec7u qu\u1ea3 v\u00e0 thi\u1ebft k\u1ebf c\u00e1c chi\u1ebfn l\u01b0\u1ee3c b\u1ed5 sung k\u1ebdm hi\u1ec7u qu\u1ea3 trong dinh d\u01b0\u1ee1ng heo con.<\/p>\n\n\n\n

      T\u00f3m l\u1ea1i, m\u1ee5c ti\u00eau l\u00e0 t\u1ea1o ra m\u1ed9t s\u1ea3n ph\u1ea9m k\u1ebdm oxit m\u00e0 khi v\u00e0o ru\u1ed9t c\u00f3 n\u1ed3ng \u0111\u1ed9 (gradient) c\u1ee5c b\u1ed9 cao Zn2+<\/sup> v\u00e0 ROS. N\u1ed3ng \u0111\u1ed9 c\u1ee5c b\u1ed9 \u0111\u00f3 ph\u1ee5 thu\u1ed9c r\u1ea5t nhi\u1ec1u v\u00e0o c\u1ea5u tr\u00fac c\u1ee7a oxit k\u1ebdm.<\/p>\n\n\n\n

      David Serene<\/p>\n\n\n\n

      Gi\u00e1m \u0111\u1ed1c Nutrispices <\/p>\n","protected":false},"excerpt":{"rendered":"

      K\u1ebdm oxit (ZnO) \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong nhi\u1ec1u th\u1eadp k\u1ef7 nh\u01b0 m\u1ed9t trong nh\u1eefng gi\u1ea3i ph\u00e1p ph\u00f2ng ng\u1eeba ti\u00eau ch\u1ea3y sau cai s\u1eefa hi\u1ec7u qu\u1ea3 nh\u1ea5t cho heo con. Hi\u1ec7u qu\u1ea3 c\u1ee7a ho\u1ea1t ch\u1ea5t n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn r\u1ed9ng r\u00e3i trong th\u1ef1c ti\u1ec5n ch\u0103n nu\u00f4i, tuy nhi\u00ean c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3 kh\u00e1 ph\u1ee9c t\u1ea1p v\u00e0 th\u01b0\u1eddng b\u1ecb \u0111\u01a1n gi\u1ea3n h\u00f3a qu\u00e1 m\u1ee9c. K\u1ebdm oxit th\u01b0\u1eddng \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 nh\u01b0 m\u1ed9t t\u00e1c nh\u00e2n kh\u00e1ng khu\u1ea9n \u0111\u01a1n gi\u1ea3n, d\u1ea7u v\u1eady c\u00e1ch hi\u1ec3u n\u00e0y ch\u01b0a ph\u1ea3n \u00e1nh \u0111\u1ea7y \u0111\u1ee7 t\u00ednh \u0111a d\u1ea1ng c\u1ee7a c\u00e1c c\u01a1 ch\u1ebf v\u1ec1 m\u1eb7t sinh-h\u00f3a-l\u00fd c\u1ee7a ho\u1ea1t ch\u1ea5t n\u00e0y. Tr\u00ean th\u1ef1c t\u1ebf, k\u1ebdm oxit t\u00e1c d\u1ee5ng th\u00f4ng qua nhi\u1ec1u con \u0111\u01b0\u1eddng b\u1ed5 tr\u1ee3 l\u1eabn nhau, ph\u1ee5 thu\u1ed9c v\u00e0o sinh l\u00fd \u0111\u01b0\u1eddng ru\u1ed9t, ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 vi sinh, c\u0169ng nh\u01b0 c\u00e1c \u0111\u1eb7c t\u00ednh n\u1ed9i t\u1ea1i c\u1ee7a ch\u00ednh ngu\u1ed3n k\u1ebdm oxit \u0110\u1ec3 hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a k\u1ebdm oxit, vi\u1ec7c l\u00e0m r\u00f5 ngu\u1ed3n g\u1ed1c c\u1ee7a vi khu\u1ea9n Escherichia coli l\u00e0 r\u1ea5t c\u1ea7n thi\u1ebft. C\u00f3 hai ngu\u1ed3n nhi\u1ec5m ch\u00ednh. Th\u1ee9 nh\u1ea5t l\u00e0 ngu\u1ed3n n\u1ed9i sinh. C\u00e1c ch\u1ee7ng E. coli v\u1ed1n hi\u1ec7n di\u1ec7n t\u1ef1 nhi\u00ean trong \u0111\u01b0\u1eddng ru\u1ed9t heo con, bao g\u1ed3m h\u1ed7ng tr\u00e0ng n\u01a1i duy tr\u00ec m\u1eadt \u0111\u1ed9 E. coli th\u1ea5p v\u00e0 trong m\u1ee9c ki\u1ec3m so\u00e1t. Tuy nhi\u00ean, sau cai s\u1eefa, nh\u1eefng thay \u0111\u1ed5i \u0111\u1ed9t ng\u1ed9t v\u1ec1 kh\u1ea9u ph\u1ea7n, stress, h\u1ec7 mi\u1ec5n d\u1ecbch c\u00f2n non y\u1ebfu v\u00e0 s\u1ef1 r\u1ed1i lo\u1ea1n nhu \u0111\u1ed9ng ru\u1ed9t \u0111\u00e3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i \u0111\u1ec3 c\u00e1c vi khu\u1ea9n n\u1ed9i t\u1ea1i n\u00e0y t\u0103ng sinh t\u1ea1i ch\u1ed7 v\u00e0 bi\u1ec3u hi\u1ec7n \u0111\u1ed9c l\u1ef1c. Th\u1ee9 hai l\u00e0 ngu\u1ed3n ngo\u1ea1i sinh. Th\u1ee9c \u0103n c\u00f3 th\u1ec3 \u0111\u01b0a vi khu\u1ea9n E.coli v\u00e0o \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, v\u00e0 ch\u00fang c\u00f3 th\u1ec3 t\u0103ng sinh trong d\u1ea1 d\u00e0y, \u0111\u1eb7c bi\u1ec7t \u1edf heo con non. Trong giai \u0111o\u1ea1n cai s\u1eefa, d\u1ecbch ti\u1ebft<\/p>\n","protected":false},"author":4,"featured_media":2306,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-2308","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutricles-vi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts\/2308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/comments?post=2308"}],"version-history":[{"count":1,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts\/2308\/revisions"}],"predecessor-version":[{"id":2323,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts\/2308\/revisions\/2323"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/media\/2306"}],"wp:attachment":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/media?parent=2308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/categories?post=2308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/tags?post=2308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}