{"id":1483,"date":"2025-08-29T16:52:58","date_gmt":"2025-08-29T09:52:58","guid":{"rendered":"https:\/\/www.nutrispices.com\/?p=1483"},"modified":"2025-12-08T14:22:47","modified_gmt":"2025-12-08T07:22:47","slug":"ba-nhom-methyl-mot-vai-tro-lon","status":"publish","type":"post","link":"https:\/\/www.nutrispices.com\/vi\/nutrinews\/nutricles\/ba-nhom-methyl-mot-vai-tro-lon\/","title":{"rendered":"Ba nh\u00f3m methyl, m\u1ed9t vai tr\u00f2 l\u1edbn"},"content":{"rendered":"\n
\"\"<\/figure>
\n

B\u1ea1n c\u00f3 th\u1ec3 ngh\u0129 r\u1eb1ng g\u00e0 ho\u1eb7c t\u00f4m l\u00e0 nh\u1eefng lo\u00e0i v\u1eadt kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng suy ngh\u0129 s\u00e2u s\u1eafc, nh\u01b0ng b\u00ean nh\u01b0ng b\u00ean trong m\u1ed7i t\u1ebf b\u00e0o c\u1ee7a ch\u00fang c\u00f3 m\u1ed9t h\u1ec7 th\u1ed1ng c\u00e2n nh\u1eafc-quy\u1ebft \u0111\u1ecbnh ph\u1ee9c t\u1ea1p d\u1ef1a tr\u00ean qu\u00e1 tr\u00ecnh methyl h\u00f3a \u2013 quy\u1ebft \u0111\u1ecbnh gene n\u00e0o \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n, ch\u1ea5t b\u00e9o n\u00e0o \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a v\u00e0 l\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 c\u00e2n b\u1eb1ng trong m\u00f4i tr\u01b0\u1eddng \u00e1p l\u1ef1c. \u0110\u00e2y l\u00e0 m\u1ed9t c\u1ed7 m\u00e1y l\u00e0m vi\u1ec7c \u0111a nhi\u1ec7m c\u00f9ng l\u00fac \u1edf t\u1ed1c \u0111\u1ed9 cao v\u00e0 t\u1ea5t c\u1ea3 \u0111\u1ec1u ph\u1ee5 thu\u1ed9c v\u00e0o m\u1ed9t y\u1ebfu t\u1ed1 then ch\u1ed1t: nh\u00f3m methyl. H\u1ed7 tr\u1ee3 chu tr\u00ecnh n\u00e0y b\u1eb1ng c\u00e1c d\u01b0\u1ee1ng ch\u1ea5t ph\u00f9 h\u1ee3p, kh\u00f4ng ch\u1ec9 l\u00e0 dinh d\u01b0\u1ee1ng th\u00f4ng minh m\u00e0 c\u00f2n l\u00e0 c\u00f4ng c\u1ee5 h\u1ed7 tr\u1ee3 v\u1eadt nu\u00f4i c\u1ee7a b\u1ea1n v\u01b0\u1ee3t qua stress.<\/strong><\/p>\n<\/div><\/div>\n\n\n

Chu tr\u00ecnh methyl h\u00f3a l\u00e0 m\u1ed9t chu\u1ed7i c\u00e1c ph\u1ea3n \u1ee9ng sinh h\u00f3a n\u01a1i m\u00e0 c\u00e1c nh\u00f3m methyl, c\u00e1c ph\u00e2n t\u1eed nh\u1ecf g\u1ed1c carbon (-CH\u2083) \u0111\u01b0\u1ee3c chuy\u1ec3n t\u1eeb ph\u00e2n t\u1eed n\u00e0y sang ph\u00e2n t\u1eed kh\u00e1c. Nh\u1eefng ph\u1ea3n \u1ee9ng n\u00e0y l\u00e0 n\u1ec1n t\u1ea3ng c\u01a1 b\u1ea3n \u0111\u1ec3 c\u00e1c t\u1ebf b\u00e0o c\u1ee7a \u0111\u1ed9ng v\u1eadt v\u1eadn h\u00e0nh.<\/span><\/p>\n

    \n
  1. S\u1ee9c kh\u1ecfe gan v\u00e0 chuy\u1ec3n h\u00f3a lipid<\/u><\/strong><\/span><\/li>\n<\/ol>\n

    Qu\u00e1 tr\u00ecnh methyl h\u00f3a tham gia v\u00e0o t\u1ed5ng h\u1ee3p phosphatidylcholine, c\u1ea7n thi\u1ebft cho vi\u1ec7c v\u1eadn chuy\u1ec3n ch\u1ea5t b\u00e9o. Thi\u1ebfu h\u1ee5t c\u00e1c ch\u1ea5t cho nh\u00f3m methyl c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn gan nhi\u1ec5m m\u1ee1, \u0111\u1eb7c bi\u1ec7t \u1edf gia c\u1ea7m v\u00e0 c\u00e1 \u0111\u01b0\u1ee3c nu\u00f4i b\u1eb1ng kh\u1ea9u ph\u1ea7n gi\u00e0u n\u0103ng l\u01b0\u1ee3ng.<\/span><\/p>\n

      \n
    1. Gi\u1ea3i \u0111\u1ed9c homocysteine<\/u><\/strong><\/span><\/li>\n<\/ol>\n

      Homocysteine l\u00e0 s\u1ea3n ph\u1ea9m ph\u1ee5 \u0111\u1ed9c h\u1ea1i s\u1ea3n sinh t\u1eeb qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a methionine. N\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c methyl h\u00f3a tr\u1edf l\u1ea1i th\u00e0nh methionine ho\u1eb7c chuy\u1ec3n th\u00e0nh cysteine, n\u00f3 c\u00f3 th\u1ec3 t\u00edch t\u1ee5 v\u00e0 g\u00e2y t\u1ed5n th\u01b0\u01a1ng cho h\u1ec7 tim m\u1ea1ch v\u00e0 th\u1ea7n kinh. Methyl h\u00f3a hi\u1ec7u qu\u1ea3 gi\u00fap ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng homocysteine.<\/span><\/p>\n

        \n
      1. T\u1ed5ng h\u1ee3p <\/u><\/strong>creatine<\/u><\/strong> v\u00e0 <\/u><\/strong>carnitine<\/u><\/strong><\/span><\/li>\n<\/ol>\n

        Hai ph\u00e2n t\u1eed n\u00e0y r\u1ea5t quan tr\u1ecdng cho n\u0103ng l\u01b0\u1ee3ng c\u01a1 b\u1eafp v\u00e0 chuy\u1ec3n h\u00f3a ch\u1ea5t b\u00e9o. Thi\u1ebfu nh\u00f3m methyl c\u00f3 th\u1ec3 khi\u1ebfn v\u1eadt nu\u00f4i kh\u00f3 t\u1ed1i \u01b0u ph\u00e1t tri\u1ec3n c\u01a1 ho\u1eb7c chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng t\u1eeb ch\u1ea5t b\u00e9o, d\u1eabn \u0111\u1ebfn ch\u1eadm l\u1edbn v\u00e0 FCR k\u00e9m.<\/span><\/p>\n

          \n
        1. Ph\u00e1t tri\u1ec3n ph\u00f4i thai <\/u><\/strong><\/span><\/li>\n<\/ol>\n

          \u1ede con gi\u1ed1ng, methyl h\u00f3a \u0111\u00f3ng vai tr\u00f2 trung t\u00e2m trong ph\u00e1t tri\u1ec3n h\u1ec7 sinh d\u1ee5c v\u00e0 ph\u00f4i, c\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y t\u1ef7 l\u1ec7 n\u1edf v\u00e0 n\u0103ng su\u1ea5t \u0111\u00e0n con \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n khi b\u1ed5 sung ch\u1ea5t cho methyl v\u00e0o kh\u1ea9u ph\u1ea7n con m\u1eb9.<\/span><\/p>\n

            \n
          1. Li\u00ean k\u1ebft k\u1ebft ch\u1eb7t t\u1ebf b\u00e0o ru\u1ed9t* <\/u><\/strong><\/span><\/li>\n<\/ol>\n

            C\u1ea5u tr\u00fac ru\u1ed9t \u2013 chi\u1ec1u cao nhung mao, c\u1ea5u tr\u00fac crypt v\u00e0 bi\u1ec3u m\u00f4 – \u0111\u1ec1u \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n b\u1edfi methyl h\u00f3a m\u1ea1nh m\u1ebd. \u0110i\u1ec1u n\u00e0y \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng trong giai \u0111o\u1ea1n \u0111\u1ea7u \u0111\u1eddi ho\u1eb7c khi v\u1eadt nu\u00f4i b\u1ecb stress \u2013 th\u1eddi \u0111i\u1ec3m m\u00e0 ch\u1ee9c n\u0103ng \u0111\u01b0\u1eddng ru\u1ed9t d\u1ec5 b\u1ecb t\u1ed5n th\u01b0\u01a1ng nh\u1ea5t.<\/span><\/p>\n

            *Gut tight junctions<\/u><\/span><\/p>\n

              \n
            1. \u0110i\u1ec1u h\u00f2a gene<\/u><\/strong><\/span><\/li>\n<\/ol>\n

              Qu\u00e1 tr\u00ecnh methyl h\u00f3a \u0111i\u1ec1u ch\u1ec9nh DNA, gi\u00fap \u201cb\u1eadt\u201d ho\u1eb7c \u201ct\u1eaft\u201d gene. C\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a bi\u1ec3u sinh (epigenetic regulation) n\u00e0y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a t\u1ebf b\u00e0o, ph\u00e1t tri\u1ec3n m\u00f4 v\u00e0 \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch. \u1ede v\u1eadt nu\u00f4i, n\u00f3 \u1ea3nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn t\u0103ng c\u01a1 b\u1eafp, kh\u1ea3 n\u0103ng sinh s\u1ea3n v\u00e0 ph\u1ea3n \u1ee9ng stress.<\/span><\/p>\n

              \u0110i\u1ec1u th\u00fa v\u1ecb nh\u1ea5t l\u00e0 methyl h\u00f3a kh\u00f4ng ch\u1ec9 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn con v\u1eadt hi\u1ec7n t\u1ea1i m\u00e0 c\u00f2n c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn th\u1ebf h\u1ec7 ti\u1ebfp theo. Th\u00f4ng qua vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh d\u1ea5u hi\u1ec7u bi\u1ec3u sinh, vi\u1ec7c b\u1ed5 sung ch\u1ea5t cho nh\u00f3m methyl trong kh\u1ea9u ph\u1ea7n c\u1ee7a heo n\u00e1i mang thai ho\u1eb7c g\u00e0 m\u00e1i gi\u1ed1ng c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ee9c kh\u1ecfe, t\u0103ng tr\u01b0\u1edfng v\u00e0 kh\u1ea3 n\u0103ng kh\u00e1ng b\u1ec7nh c\u1ee7a th\u1ebf h\u1ec7 con. Trong b\u1ed1i c\u1ea3nh n\u00e0y, h\u1ed7 tr\u1ee3 methyl h\u00f3a kh\u00f4ng ch\u1ec9 l\u00e0 chi\u1ebfn l\u01b0\u1ee3c dinh d\u01b0\u1ee1ng m\u00e0 c\u00f2n l\u00e0 \u0111\u1ea7u t\u01b0 cho n\u0103ng su\u1ea5t trong d\u00e0i h\u1ea1n.<\/span><\/p>\n

              S\u1ef1 methyl h\u00f3a hi\u1ec7u su\u1ea5t cao ph\u1ee5 thu\u1ed9c v\u00e0o vi\u1ec7c cung c\u1ea5p li\u00ean t\u1ee5c c\u00e1c ch\u1ea5t cho nh\u00f3m methyl v\u00e0 c\u00e1c \u0111\u1ed3ng y\u1ebfu t\u1ed1 (cofactors). Chuy\u00ean gia dinh d\u01b0\u1ee1ng c\u1ea7n \u0111\u1ea3m b\u1ea3o r\u1eb1ng kh\u1ea9u ph\u1ea7n \u0103n cung c\u1ea5p \u0111\u1ee7 c\u00e1c ch\u1ea5t n\u00e0y.<\/span><\/p>\n

              Methionine<\/strong> \u2013 l\u00e0 ngu\u1ed3n cung c\u1ea5p methyl ch\u00ednh trong chu tr\u00ecnh. \u0110\u00e2y l\u00e0 m\u1ed9t axit amin c\u00f3 ch\u1ee9a m\u1ed9t nh\u00f3m methyl. Ngo\u00e0i vai tr\u00f2 x\u00e2y d\u1ef1ng protein, methionine c\u00f2n l\u00e0 ch\u1ea5t cho methyl r\u1ea5t quan tr\u1ecdng. Tuy nhi\u00ean, n\u00f3 c\u0169ng l\u00e0 m\u1ed9t trong nh\u1eefng axit amin \u0111\u1eaft \u0111\u1ecf nh\u1ea5t trong kh\u1ea9u ph\u1ea7n.<\/span><\/p>\n

              Choline<\/strong> \u2013 h\u1ed7 tr\u1ee3 c\u1ea5u tr\u00fac m\u00e0ng t\u1ebf b\u00e0o th\u00f4ng qua qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p phosphatidylcholine, \u0111\u1ed3ng th\u1eddi c\u0169ng l\u00e0 ch\u1ea5t cho methyl. D\u00f9 c\u00f3 ba nh\u00f3m methyl trong c\u1ea5u tr\u00fac, choline ch\u1ec9 cung c\u1ea5p \u0111\u01b0\u1ee3c m\u1ed9t nh\u00f3m methyl cho chu tr\u00ecnh n\u00e0y.<\/span><\/p>\n

              Betaine<\/strong> \u2013 t\u00ean khoa h\u1ecdc l\u00e0 trimethylglycine, c\u00f4ng th\u1ee9c ph\u00e2n t\u1eed C\u2085H\u2081\u2081NO\u2082, l\u00e0 m\u1ed9t trong nh\u1eefng ch\u1ea5t cho methyl hi\u1ec7u qu\u1ea3 nh\u1ea5t trong chuy\u1ec3n h\u00f3a \u1edf \u0111\u1ed9ng v\u1eadt. N\u00f3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb choline ho\u1eb7c b\u1ed5 sung tr\u1ef1c ti\u1ebfp v\u00e0o kh\u1ea9u ph\u1ea7n. Ngo\u00e0i vai tr\u00f2 methyl h\u00f3a, betaine c\u00f2n ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t \u0111i\u1ec1u h\u00f2a \u00e1p su\u1ea5t th\u1ea9m th\u1ea5u, gi\u00fap t\u1ebf b\u00e0o duy tr\u00ec c\u1ea5u tr\u00fac v\u00e0 c\u00e2n b\u1eb1ng n\u01b0\u1edbc d\u01b0\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n stress nh\u01b0 nhi\u1ec7t, cai s\u1eefa ho\u1eb7c m\u00f4i tr\u01b0\u1eddng n\u01b0\u1edbc m\u1eb7n.<\/span><\/p>\n

              Vitamin B9 & B12<\/strong> \u2013 kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ea5t cho methyl tr\u1ef1c ti\u1ebfp nh\u01b0ng \u0111\u00f3ng vai tr\u00f2 \u0111\u1ed3ng y\u1ebfu t\u1ed1 trong qu\u00e1 tr\u00ecnh chuy\u1ec3n nh\u00f3m methyl. N\u1ebfu thi\u1ebfu, chu tr\u00ecnh methyl h\u00f3a s\u1ebd ch\u1eadm l\u1ea1i v\u00e0 homocysteine s\u1ebd t\u00edch t\u1ee5. Hai vitamin n\u00e0y \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng v\u1edbi con non v\u00e0 th\u00fa mang thai.<\/span><\/p>\n

              \"Betaine,
              Betaine, Choline, and Methionine l\u00e0 nh\u1eefng nh\u00f3m Cho Methyl ch\u1ee7 y\u1ebfu<\/figcaption><\/figure>\n

              Trong th\u1ef1c t\u1ebf, methionine, choline v\u00e0 betaine \u0111\u1ec1u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00f4ng th\u1ee9c kh\u1ea9u ph\u1ea7n \u0111\u1ec3 h\u1ed7 tr\u1ee3 c\u00e1c con \u0111\u01b0\u1eddng n\u00e0y. Tuy nhi\u00ean, betaine n\u1ed5i b\u1eadt nh\u1edd hi\u1ec7u qu\u1ea3 cao trong vi\u1ec7c cung c\u1ea5p nh\u00f3m methyl. X\u00e9t v\u1ec1 thay th\u1ebf, 1kg betaine c\u00f3 th\u1ec3 thay th\u1ebf kho\u1ea3ng 2.5 \u0111\u1ebfn 3kg choline chloride 60%, d\u1ef1a tr\u00ean quy \u0111\u1ed5i nh\u00f3m methyl.<\/span><\/p>\n

              Betaine hi\u1ec7u qu\u1ea3 h\u01a1n choline v\u00ec ho\u1ea1t \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp v\u00e0 t\u1ee9c th\u00ec. Choline c\u1ea7n tr\u1ea3i qua nhi\u1ec1u b\u01b0\u1edbc chuy\u1ec3n h\u00f3a trong gan \u0111\u1ec3 tr\u1edf th\u00e0nh betaine, trong khi betaine c\u00f3 th\u1ec3 ngay l\u1eadp t\u1ee9c cung c\u1ea5p nh\u00f3m methyl \u0111\u1ec3 t\u00e1i methyl h\u00f3a homocysteine th\u00e0nh methionine. Qu\u00e1 tr\u00ecnh n\u00e0y nhanh h\u01a1n, hi\u1ec7u qu\u1ea3 h\u01a1n v\u00e0 kh\u00f4ng c\u1ea7n enzyme, n\u0103ng l\u01b0\u1ee3ng hay \u0111\u1ed3ng y\u1ebfu t\u1ed1 nh\u01b0 folate ho\u1eb7c vitamin B12. Trong \u0111i\u1ec1u ki\u1ec7n stress chuy\u1ec3n h\u00f3a, khi c\u00e1c y\u1ebfu t\u1ed1 tr\u00ean b\u1ecb \u1ea3nh h\u01b0\u1edfng, betaine v\u1eabn duy tr\u00ec hi\u1ec7u qu\u1ea3 cao.<\/span><\/p>\n

              \"\"<\/p>\n

              Tuy nhi\u00ean, betaine kh\u00f4ng th\u1ec3 thay th\u1ebf ho\u00e0n to\u00e0n ch\u1ee9c n\u0103ng c\u1ee7a choline. Choline c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p acetylcholine \u2013 m\u1ed9t ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh \u2013 v\u00e0 phosphatidylcholine \u2013 th\u00e0nh ph\u1ea7n c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o. V\u00ec v\u1eady, kh\u00f4ng n\u00ean thay th\u1ebf ho\u00e0n to\u00e0n, m\u00e0 ch\u1ec9 thay th\u1ebf m\u1ed9t ph\u1ea7n theo t\u1ef7 l\u1ec7 3:1 (betaine : choline) l\u00e0 ph\u00f9 h\u1ee3p v\u00e0 mang l\u1ea1i l\u1ee3i \u00edch.<\/span><\/p>\n

              Betaine c\u0169ng c\u00f3 th\u1ec3 thay th\u1ebf methionine theo t\u1ef7 l\u1ec7 1:1 v\u1ec1 m\u1eb7t cung c\u1ea5p nh\u00f3m methyl. Tuy nhi\u00ean, \u0111\u1ec3 c\u00f3 th\u1ec3 cho methyl th\u00ec methionine c\u1ea7n \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh S-adenosylmethionine (SAM) – \u00a0qu\u00e1 tr\u00ecnh n\u00e0y ti\u00eau t\u1ed1n nhi\u1ec1u n\u0103ng l\u01b0\u1ee3ng h\u01a1n so v\u1edbi betaine.<\/span><\/p>\n

              Betaine kh\u00f4ng th\u1ec3 ho\u00e0n to\u00e0n thay th\u1ebf methionine v\u00ec methionine kh\u00f4ng ch\u1ec9 l\u00e0 ch\u1ea5t cho methyl m\u00e0 c\u00f2n l\u00e0 axit amin thi\u1ebft y\u1ebfu cho t\u1ed5ng h\u1ee3p protein v\u00e0 ph\u00e1t tri\u1ec3n m\u00f4. Do \u0111\u00f3, d\u00f9 betaine gi\u00fap ti\u1ebft ki\u1ec7m methionine cho qu\u00e1 tr\u00ecnh methyl h\u00f3a, v\u1eabn c\u1ea7n m\u1ed9t l\u01b0\u1ee3ng methionine t\u1ed1i thi\u1ec3u trong kh\u1ea9u ph\u1ea7n \u0111\u1ec3 \u0111\u00e1p \u1ee9ng nhu c\u1ea7u c\u1ea5u tr\u00fac v\u00e0 trao \u0111\u1ed5i ch\u1ea5t.<\/span><\/p>\n

              Trong minh h\u1ecda d\u01b0\u1edbi \u0111\u00e2y, kh\u1ea9u ph\u1ea7n ti\u00eau chu\u1ea9n cho g\u00e0 th\u1ecbt ch\u1ee9a 3kg DL-Methionine v\u00e0 1.5kg Choline Chloride 60% m\u1ed7i t\u1ea5n th\u1ee9c \u0103n. Sau khi thay th\u1ebf m\u1ed9t ph\u1ea7n b\u1eb1ng betaine, \u0111\u00e3 ti\u1ebft ki\u1ec7m \u0111\u01b0\u1ee3c 0.80 USD m\u1ed7i t\u1ea5n.<\/span><\/p>\n

              \"\"<\/p>\n

              Ngo\u00e0i ti\u1ebft ki\u1ec7m chi ph\u00ed s\u1ea3n xu\u1ea5t, vi\u1ec7c thay th\u1ebf choline ho\u1eb7c methionine b\u1eb1ng betaine c\u00f2n mang l\u1ea1i l\u1ee3i \u00edch sinh h\u1ecdc. Betaine gi\u00fap t\u0103ng c\u01b0\u1eddng s\u1ee9c kh\u1ecfe ru\u1ed9t b\u1eb1ng c\u00e1ch duy tr\u00ec cung c\u1ea5p n\u01b0\u1edbc t\u1ebf b\u00e0o v\u00e0 b\u1ea3o v\u1ec7 c\u00e1c li\u00ean k\u1ebft ch\u1eb7t \u1edf t\u1ebf b\u00e0o ru\u1ed9t. \u0110i\u1ec1u n\u00e0y \u0111\u1eb7c bi\u1ec7t h\u1eefu \u00edch trong giai \u0111o\u1ea1n stress nhi\u1ec7t ho\u1eb7c \u0111\u1ea7u \u0111\u1eddi, khi \u0111\u01b0\u1eddng ru\u1ed9t v\u1eadt nu\u00f4i ch\u01b0a ph\u00e1t tri\u1ec3n ho\u00e0n to\u00e0n ho\u1eb7c giai \u0111o\u1ea1n cai s\u1eefa. \u1ede th\u1ee7y s\u1ea3n, betaine c\u1ea3i thi\u1ec7n \u0111\u1ed9 ngon mi\u1ec7ng c\u1ee7a th\u1ee9c \u0103n v\u00e0 kh\u1ea3 n\u0103ng \u0111i\u1ec1u h\u00f2a \u00e1p su\u1ea5t th\u1ea9m th\u1ea5u \u2013 \u0111i\u1ec1u r\u1ea5t quan tr\u1ecdng trong m\u00f4i tr\u01b0\u1eddng n\u01b0\u1edbc m\u1eb7n. Cu\u1ed1i c\u00f9ng, betaine c\u00f3 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh cao h\u01a1n trong premix v\u00e0 th\u1ee9c \u0103n vi\u00ean, gi\u00fap gi\u1ea3i quy\u1ebft c\u00e1c v\u1ea5n \u0111\u1ec1 m\u00e0 choline chloride g\u00e2y ra nh\u01b0 h\u00fat \u1ea9m v\u00e0 d\u1ec5 bi\u1ebfn ch\u1ea5t trong qu\u00e1 tr\u00ecnh b\u1ea3o qu\u1ea3n.<\/span><\/p>\n

              K\u1ebft lu\u1eadn<\/strong><\/span><\/p>\n

              Chu tr\u00ecnh methyl h\u00f3a l\u00e0 n\u1ec1n t\u1ea3ng chuy\u1ec3n h\u00f3a trong sinh l\u00fd \u0111\u1ed9ng v\u1eadt, \u1ea3nh h\u01b0\u1edfng v\u01b0\u1ee3t xa c\u00e1c th\u00f4ng s\u1ed1 t\u0103ng tr\u01b0\u1edfng c\u01a1 b\u1ea3n. H\u1ed7 tr\u1ee3 chu tr\u00ecnh n\u00e0y v\u1edbi s\u1ef1 c\u00e2n b\u1eb1ng h\u1ee3p l\u00fd gi\u1eefa methionine, choline v\u00e0 betaine c\u00f3 th\u1ec3 mang l\u1ea1i c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 v\u1ec1 n\u0103ng su\u1ea5t, s\u1ee9c \u0111\u1ec1 kh\u00e1ng c\u1ee7a v\u1eadt nu\u00f4i v\u00e0 chi ph\u00ed s\u1ea3n xu\u1ea5t. D\u00f9 betaine c\u00f3 v\u1ebb \u0111\u1eaft h\u01a1n tr\u00ean m\u1ed7i kg, nh\u01b0ng hi\u1ec7u su\u1ea5t v\u01b0\u1ee3t tr\u1ed9i, ch\u1ee9c n\u0103ng sinh h\u1ecdc b\u1ed5 sung v\u00e0 kh\u1ea3 n\u0103ng linh ho\u1ea1t trong c\u00f4ng th\u1ee9c khi\u1ebfn n\u00f3 tr\u1edf th\u00e0nh m\u1ed9t th\u00e0nh ph\u1ea7n chi\u1ebfn l\u01b0\u1ee3c trong kh\u1ea9u ph\u1ea7n hi\u1ec7n \u0111\u1ea1i. N\u1ebfu \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u00fang c\u00e1ch, n\u00f3 kh\u00f4ng ch\u1ec9 l\u00e0 ch\u1ea5t thay th\u1ebf m\u00e0 c\u00f2n l\u00e0 c\u00f4ng c\u1ee5 \u0111\u1ec3 n\u00e2ng cao l\u1ee3i nhu\u1eadn v\u00e0 hi\u1ec7u qu\u1ea3.<\/span><\/p>\n

              David Serene<\/span><\/strong><\/p>\n

              Gi\u00e1m \u0111\u1ed1c Nutrispices<\/span><\/p>","protected":false},"excerpt":{"rendered":"

              B\u1ea1n c\u00f3 th\u1ec3 ngh\u0129 r\u1eb1ng g\u00e0 ho\u1eb7c t\u00f4m l\u00e0 nh\u1eefng lo\u00e0i v\u1eadt kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng suy ngh\u0129 s\u00e2u s\u1eafc, nh\u01b0ng b\u00ean nh\u01b0ng b\u00ean trong m\u1ed7i t\u1ebf b\u00e0o c\u1ee7a ch\u00fang c\u00f3 m\u1ed9t h\u1ec7 th\u1ed1ng c\u00e2n nh\u1eafc-quy\u1ebft \u0111\u1ecbnh ph\u1ee9c t\u1ea1p d\u1ef1a tr\u00ean qu\u00e1 tr\u00ecnh methyl h\u00f3a \u2013 quy\u1ebft \u0111\u1ecbnh gene n\u00e0o \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n, ch\u1ea5t b\u00e9o n\u00e0o \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a v\u00e0 l\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 c\u00e2n b\u1eb1ng trong m\u00f4i tr\u01b0\u1eddng \u00e1p l\u1ef1c. \u0110\u00e2y l\u00e0 m\u1ed9t c\u1ed7 m\u00e1y l\u00e0m vi\u1ec7c \u0111a nhi\u1ec7m c\u00f9ng l\u00fac \u1edf t\u1ed1c \u0111\u1ed9 cao v\u00e0 t\u1ea5t c\u1ea3 \u0111\u1ec1u ph\u1ee5 thu\u1ed9c v\u00e0o m\u1ed9t y\u1ebfu t\u1ed1 then ch\u1ed1t: nh\u00f3m methyl. H\u1ed7 tr\u1ee3 chu tr\u00ecnh n\u00e0y b\u1eb1ng c\u00e1c d\u01b0\u1ee1ng ch\u1ea5t ph\u00f9 h\u1ee3p, kh\u00f4ng ch\u1ec9 l\u00e0 dinh d\u01b0\u1ee1ng th\u00f4ng minh m\u00e0 c\u00f2n l\u00e0 c\u00f4ng c\u1ee5 h\u1ed7 tr\u1ee3 v\u1eadt nu\u00f4i c\u1ee7a b\u1ea1n v\u01b0\u1ee3t qua stress. Chu tr\u00ecnh methyl h\u00f3a l\u00e0 m\u1ed9t chu\u1ed7i c\u00e1c ph\u1ea3n \u1ee9ng sinh h\u00f3a n\u01a1i m\u00e0 c\u00e1c nh\u00f3m methyl, c\u00e1c ph\u00e2n t\u1eed nh\u1ecf g\u1ed1c carbon (-CH\u2083) \u0111\u01b0\u1ee3c chuy\u1ec3n t\u1eeb ph\u00e2n t\u1eed n\u00e0y sang ph\u00e2n t\u1eed kh\u00e1c. Nh\u1eefng ph\u1ea3n \u1ee9ng n\u00e0y l\u00e0 n\u1ec1n t\u1ea3ng c\u01a1 b\u1ea3n \u0111\u1ec3 c\u00e1c t\u1ebf b\u00e0o c\u1ee7a \u0111\u1ed9ng v\u1eadt v\u1eadn h\u00e0nh. S\u1ee9c kh\u1ecfe gan v\u00e0 chuy\u1ec3n h\u00f3a lipid Qu\u00e1 tr\u00ecnh methyl h\u00f3a tham gia v\u00e0o t\u1ed5ng h\u1ee3p phosphatidylcholine, c\u1ea7n thi\u1ebft cho vi\u1ec7c v\u1eadn chuy\u1ec3n ch\u1ea5t b\u00e9o. Thi\u1ebfu h\u1ee5t c\u00e1c ch\u1ea5t cho nh\u00f3m methyl c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn gan nhi\u1ec5m m\u1ee1, \u0111\u1eb7c bi\u1ec7t \u1edf gia c\u1ea7m v\u00e0 c\u00e1 \u0111\u01b0\u1ee3c nu\u00f4i b\u1eb1ng kh\u1ea9u ph\u1ea7n gi\u00e0u n\u0103ng l\u01b0\u1ee3ng. Gi\u1ea3i \u0111\u1ed9c homocysteine Homocysteine l\u00e0 s\u1ea3n ph\u1ea9m ph\u1ee5 \u0111\u1ed9c h\u1ea1i s\u1ea3n sinh t\u1eeb qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a methionine. N\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c methyl h\u00f3a tr\u1edf l\u1ea1i th\u00e0nh methionine ho\u1eb7c chuy\u1ec3n th\u00e0nh cysteine, n\u00f3 c\u00f3 th\u1ec3 t\u00edch t\u1ee5 v\u00e0 g\u00e2y t\u1ed5n th\u01b0\u01a1ng cho h\u1ec7 tim m\u1ea1ch v\u00e0 th\u1ea7n kinh. Methyl h\u00f3a hi\u1ec7u qu\u1ea3 gi\u00fap ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng homocysteine. T\u1ed5ng h\u1ee3p creatine v\u00e0 carnitine Hai<\/p>\n","protected":false},"author":4,"featured_media":1464,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[36],"tags":[74,67,68,69],"class_list":["post-1483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutricles-vi","tag-nutricle","tag-betaine","tag-methyl","tag-david-serene"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts\/1483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/comments?post=1483"}],"version-history":[{"count":5,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts\/1483\/revisions"}],"predecessor-version":[{"id":2130,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/posts\/1483\/revisions\/2130"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/media\/1464"}],"wp:attachment":[{"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/media?parent=1483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/categories?post=1483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nutrispices.com\/vi\/wp-json\/wp\/v2\/tags?post=1483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}